Royal Air Force Typhoon fighter aircraft have conducted a mission with French aircraft in a combined operation against an subterranean weapons facility in Syria employed by the IS group, according to the UK's MoD.
The facility, pinpointed through surveillance, was thought to be containing munitions and bombs, the statement said, and was located in hills just above Palmyra in the heart of Syria.
"The RAF jets used Paveway IV guided bombs to strike a number of approach shafts leading to the facility... early reports indicate the target was engaged successfully," the MoD said.
There was no evidence of any civilian casualties in the attack conducted Saturday night and every plane involved returned to base without incident, the ministry further stated.
The Typhoon fighters were supported by a Voyager tanker plane.
IS - referred to as ISIS - imposed jihadist rule over large swathes of both Syria and Iraq before its territorial defeat in 2019.
"This strike underscores British leadership, and determination to operate in unison with our allies, to eliminate any revival of the terrorist group and their harmful and extremist ideologies in the Middle East," Britain's Defence Chief John Healey said.
UK warplanes have carried out surveillance missions over Syrian airspace to "forestall any attempted comeback" of the group following its routing at the climactic battle in Baghuz in 2019, the ministry said.
"I must thank all the members of our armed forces involved in this strike for their professionalism and their bravery," he added. "They were part of thousands of UK service members on duty over the holidays. This action, to remove militants who threaten our security, demonstrates how UK forces are ready to step up, throughout the year, ensuring Britain's security domestically and powerful internationally."
During December, the United States armed forces executed what it called a "massive strike" on IS targets in the country, after an attack killed two American soldiers and a civilian linguist in the Palmyra area.
The United Nations estimates Daesh still has roughly 5-7 thousand combatants in Syria and Iraq.